Clark's Fixative Solution

Clark’s fixative solution is an effective, acidic, general fixative used with a good result on smears and frozen sections.  The fixation time is 3-4 hours, and the fixed specimen must not be left in the solution beyond that time, though the specimen may be transferred directly to 95% ethanol for longer storage.  It preserves nucleic acids and dissolves lipids.  Hempstead Halide sells smaller quantities in wide-mouth bottles to allow fixation directly in the bottle without decanting.  Use all appropriate safety measures when working with Clark’s fixative solution.  Refer to the relevant safety data sheet(s).